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Pain scores improved by approximately 76% on the WOMAC scale, and more than 12% of Retatrutide-treated participants reported complete freedom from knee pain at week 68, compared to 4.2% on placebo

Substantial weight loss may reduce knee loading and improve symptoms, but clinically relevant loss of lean mass may worsen sarcopenia, quadriceps weakness, balance, walking capacity, and postoperative recovery

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Frequency is twice daily